ZNF682 Polyclonal Antibody

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 682 (ZNF682) is a 498 amino acid member of the Krueppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF682 contains eleven C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation. Two isoforms of ZNF682 exist as a result of alternative splicing events.

The ZNF682 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of ZNF682 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human ZNF682 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The ZNF682 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 150 kDa in Western blot analysis of human cell lysates. In addition, it shows strong staining of the nucleus in formalin-fixed, paraffin-embedded human tissues in immunohistochemistry.

This antibody is suitable for use in a wide range of research applications, including studies of gene expression, protein localization, and protein-protein interactions. It is an essential tool for researchers investigating the role of ZNF682 in various biological processes, including development, differentiation, and disease.

In summary, the ZNF682 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of ZNF682 protein in various biological samples. Its extensive validation and broad range of applications make it an essential tool for researchers investigating the role of ZNF682 in various biological processes.