VHR Polyclonal Antibody

Dual specificity protein phosphatase 3 encoded by DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

The VHR Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated to ensure optimal performance. The VHR Polyclonal Antibody is ideal for use in immunohistochemistry, western blotting, and other protein detection assays.

This antibody is designed to target the VHR protein, which is a member of the dual-specificity phosphatase family. The VHR protein is involved in various cellular processes, including cell cycle regulation, DNA damage response, and stress signaling. The VHR Polyclonal Antibody is highly specific to the VHR protein and does not cross-react with other proteins, ensuring accurate and reliable results.

The VHR Polyclonal Antibody is available in various sizes and formats to suit different research needs. It is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. This antibody is stable for long-term storage at -20°C and can be used for multiple experiments.

Overall, the VHR Polyclonal Antibody is a reliable and effective tool for researchers studying the VHR protein and its role in various cellular processes. Its high specificity and sensitivity make it an ideal choice for a wide range of research applications.