VE-Cadherin Polyclonal Antibody

Vascular endothelial (VE)-cadherin (VE-CAD), also called 7B4 and cadherin‑5 (CDH5), is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium‑dependent transmembrane proteins which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. VE-cadherin has been shown to play important roles in vasculogenesis and angiogenesis. VE-cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. Human VE-cadherin is a 784 amino acid (aa) residue protein with a 25 aa signal sequence and a 759 aa propeptide. The mature protein begins at amino acid 48 and has a 546 aa extracellular domain, a 27 aa transmembrane domain, and a 164 aa cytoplasmic domain. The human and mouse mature VE-cadherin proteins share approximately 74% homology.The VE-Cadherin Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of VE-Cadherin protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.

VE-Cadherin, also known as vascular endothelial cadherin or CDH5, is a transmembrane glycoprotein that plays a crucial role in the maintenance of endothelial cell integrity and vascular development. It is predominantly expressed in endothelial cells and is involved in cell-cell adhesion, regulating vascular permeability, and angiogenesis.

The VE-Cadherin Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes the native and denatured forms of VE-Cadherin protein, enabling accurate and reliable detection in both normal and pathological tissues.

This antibody has been extensively validated and characterized to ensure consistent and reproducible results. It exhibits minimal cross-reactivity with other related proteins, ensuring specificity in target detection. Additionally, it demonstrates excellent sensitivity, allowing for the detection of low levels of VE-Cadherin expression.

The VE-Cadherin Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex preparation steps. It is provided in a convenient format, allowing for easy storage and handling.

In summary, the VE-Cadherin Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of VE-Cadherin protein expression. With its exceptional performance and ease of use, it is an essential reagent for researchers and scientists studying vascular biology, angiogenesis, and endothelial cell function.