V-ATPase B1 Polyclonal Antibody

ATP6V1B1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. V-type proton ATPase subunit B kidney isoform is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness.

The V-ATPase B1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of V-ATPase B1 protein in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, ensuring its exceptional sensitivity and specificity.

The V-ATPase B1 Polyclonal Antibody exhibits a high affinity towards the V-ATPase B1 protein, enabling accurate and precise detection even at low concentrations. It has been extensively validated through rigorous testing procedures, guaranteeing its consistent performance and reproducibility.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It provides researchers with a valuable tool for investigating the expression and localization of V-ATPase B1 in various tissues and cell types.

The V-ATPase B1 Polyclonal Antibody is manufactured under strict quality control standards, ensuring its superior performance and reliability. It is supplied in a convenient and ready-to-use format, allowing for easy and efficient experimentation.

Choose the V-ATPase B1 Polyclonal Antibody for its exceptional specificity, sensitivity, and reliability. It is an indispensable tool for researchers in the field of molecular biology, cell biology, and biochemistry, facilitating the advancement of scientific knowledge and discovery.