USP13 Polyclonal Antibody

Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzyme (DUB) action. Five DUB subfamilies are recognized, including the USP, UCH, OTU, MJD, and JAMM enzymes. Ubiquitin carboxyl-terminal hydrolase 13 (USP13; isopeptidase T-3) contains four ubiquitin-associated/translation elongation factor EF1B, amino terminal (UBA) domains and one ubiquitin-specific processing protease (UBP) domain. The UBP domain of USP13 contains a catalytic site, a zinc finger domain, and two UBA domains. Similar to other USP family members, USP13 contains cysteines and histidines that are likely involved in its catalytic mechanism. Studies show that USP13 plays a critical role in autophagy through the deubiquitination of target proteins such as BECN1 and USP10. Research also suggests that USP13 is implicated in the pathogenesis of melanoma through its ability to regulate the ubiquitination status of MITF.

The USP13 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of USP13 protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional sensitivity and specificity.

USP13, also known as ubiquitin-specific protease 13, is a deubiquitinating enzyme that plays a crucial role in regulating various cellular processes, including protein degradation, DNA repair, and signal transduction. Dysregulation of USP13 has been implicated in the pathogenesis of several diseases, making it an important target for research and therapeutic interventions.

The USP13 Polyclonal Antibody has been rigorously validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It demonstrates a high affinity for USP13 protein, ensuring accurate and reliable detection with minimal background interference.

This antibody is produced using state-of-the-art recombinant technology, ensuring batch-to-batch consistency and high purity. It is supplied as a liquid formulation, ready for immediate use, and is compatible with a wide range of experimental conditions and sample types.

With its exceptional specificity and sensitivity, the USP13 Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of USP13 in cellular processes and disease mechanisms. Its reliable performance and ease of use make it an ideal choice for both basic research and clinical applications.

Order your USP13 Polyclonal Antibody today and unlock new insights into the intricate workings of USP13 protein and its implications in various biological processes.