TWEAK Polyclonal Antibody

Tumor necrosis factor ligand superfamily member 12 encoded by TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID: 407977, TNFSF12-TNFSF13.

The TWEAK Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of TWEAK protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human TWEAK protein. The resulting polyclonal antibody exhibits high affinity and specificity towards TWEAK protein, making it an ideal tool for various applications in research and diagnostics.

The TWEAK Polyclonal Antibody is validated for use in Western blotting, immunohistochemistry, and ELISA assays. It has been shown to detect TWEAK protein in a variety of human tissues and cell lines, including liver, kidney, lung, and breast cancer cells. The antibody is also suitable for use in other applications, such as immunoprecipitation and flow cytometry.

This antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using protein A chromatography. It is provided in a liquid form, with a concentration of 1 mg/mL, and is available in various sizes to meet the needs of different experiments. The TWEAK Polyclonal Antibody is stored at -20°C and should be thawed and diluted prior to use.

In summary, the TWEAK Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of TWEAK protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers and clinicians working in the fields of immunology, oncology, and inflammation.