Tubulin  Alpha1/3/4 Polyclonal Antibody

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A (tubulin alpha 1a) encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The Tubulin Alpha1/3/4 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of tubulin alpha isoforms 1, 3, and 4. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards its target proteins.

Tubulin alpha isoforms play a crucial role in the formation and maintenance of microtubules, which are essential components of the cytoskeleton. By binding to tubulin alpha isoforms 1, 3, and 4, this polyclonal antibody enables researchers to investigate their involvement in various cellular processes, including cell division, intracellular transport, and cell morphology.

The Tubulin Alpha1/3/4 Polyclonal Antibody exhibits exceptional sensitivity and selectivity, making it an ideal choice for immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications. Its robust performance ensures accurate and reproducible results, facilitating comprehensive studies on tubulin alpha isoforms in diverse biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been rigorously validated for its specificity and functionality, ensuring optimal performance in various experimental settings. Additionally, it is compatible with multiple species, including human, mouse, and rat, broadening its applicability across different research fields.

Choose the Tubulin Alpha1/3/4 Polyclonal Antibody for its exceptional quality, reliability, and versatility. With its ability to specifically detect tubulin alpha isoforms 1, 3, and 4, this antibody will undoubtedly contribute to advancing your research in the field of cellular biology and beyond.