Tubulin  Alpha (Acetyl Lys352) Polyclonal Antibody

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that TUBA1A expression is predominantly found in morphologically differentiated neurologic cells. TUBA1A is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The Tubulin Alpha (Acetyl Lys352) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Tubulin Alpha protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the acetylated Lys352 region of the Tubulin Alpha protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the acetylated Lys352 region of Tubulin Alpha, making it an ideal tool for studying the post-translational modifications of this protein.

The Tubulin Alpha (Acetyl Lys352) Polyclonal Antibody is suitable for use in a variety of applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It has been validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other related proteins. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

Overall, the Tubulin Alpha (Acetyl Lys352) Polyclonal Antibody is a reliable and high-quality reagent that can be used to investigate the role of Tubulin Alpha in various biological processes, including cell division, intracellular transport, and cytoskeletal organization. Its high specificity and sensitivity make it an essential tool for researchers studying the complex mechanisms underlying these processes.