Tubulin  Alpha (Acetyl Lys112) Polyclonal Antibody

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that TUBA1A expression is predominantly found in morphologically differentiated neurologic cells. TUBA1A is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The Tubulin Alpha (Acetyl Lys112) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Tubulin Alpha protein in various biological samples. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards the acetylated Lys112 residue of Tubulin Alpha.

The Tubulin Alpha (Acetyl Lys112) Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to investigate the expression, localization, and post-translational modifications of Tubulin Alpha in diverse cellular contexts.

This antibody is meticulously validated to ensure consistent and reliable results. It demonstrates minimal cross-reactivity with other tubulin isoforms, ensuring accurate and specific detection of Tubulin Alpha. Furthermore, it exhibits excellent sensitivity, allowing for the detection of low-abundance Tubulin Alpha protein levels.

The Tubulin Alpha (Acetyl Lys112) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy storage and handling.

In summary, the Tubulin Alpha (Acetyl Lys112) Polyclonal Antibody is a valuable tool for researchers studying Tubulin Alpha protein and its acetylation at Lys112. With its exceptional specificity, sensitivity, and versatility, this antibody enables precise and accurate analysis of Tubulin Alpha in various experimental settings.