TRAF2 Polyclonal Antibody

TNF receptor-associated factor 2 encoded by TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

The TRAF2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of TRAF2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards TRAF2.

TRAF2, also known as TNF receptor-associated factor 2, is a key signaling molecule involved in the regulation of various cellular processes, including immune response, apoptosis, and inflammation. It plays a crucial role in the activation of NF-κB and JNK signaling pathways, which are essential for cell survival and proliferation.

The TRAF2 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of TRAF2 protein expression in both normal and disease-related samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The TRAF2 Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the TRAF2 Polyclonal Antibody is a valuable tool for researchers studying the role of TRAF2 in various biological processes. Its high specificity, sensitivity, and reliability make it an ideal choice for protein expression analysis in both basic and clinical research settings.