TRADD Polyclonal Antibody

Tumor necrosis factor receptor type 1-associated DEATH domain protein encoded by TRADD is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. Tumor necrosis factor receptor type 1-associated DEATH domain protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

The TRADD Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of TRADD protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human TRADD protein. The resulting polyclonal antibody exhibits high affinity and specificity towards TRADD protein, making it an ideal tool for various applications such as Western blotting, immunoprecipitation, and immunohistochemistry.

The TRADD Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. It has been shown to detect endogenous TRADD protein in various cell lines and tissues, and can be used to study the role of TRADD in various cellular processes such as apoptosis, inflammation, and immune response.

This antibody is supplied as a purified IgG fraction, and is available in various sizes to suit different experimental needs. It is recommended to use this antibody at a dilution of 1:1000 for Western blotting, and 1:50 for immunohistochemistry. The TRADD Polyclonal Antibody is a reliable and high-quality reagent that can help researchers advance their understanding of TRADD protein and its role in various biological processes.