Topo IIBeta Polyclonal Antibody

TOP2B (topoisomerase (DNA) II beta) encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. TOP2B encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in TOP2B have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of TOP2B results in two transcript variants; however, the second variant has not yet been fully described.

The Topo IIBeta Polyclonal Antibody is a highly reliable and efficient tool designed for the detection and analysis of Topoisomerase IIBeta protein in various biological samples. This antibody is produced using advanced techniques, ensuring exceptional specificity and sensitivity.

With its superior performance, this polyclonal antibody enables accurate identification and quantification of Topo IIBeta protein in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its exceptional affinity towards the target protein guarantees reliable and reproducible results, making it an indispensable tool for researchers in the field.

The Topo IIBeta Polyclonal Antibody exhibits minimal cross-reactivity with other related proteins, ensuring precise and specific detection. Its high-quality formulation ensures stability and long shelf life, allowing for consistent and reliable results over time.

This antibody is supplied in a convenient and user-friendly format, making it easy to handle and store. It is compatible with various experimental conditions and can be used in both routine laboratory settings and advanced research applications.

In summary, the Topo IIBeta Polyclonal Antibody is a top-tier product that offers exceptional performance, reliability, and versatility. Its outstanding specificity, sensitivity, and stability make it an ideal choice for researchers seeking accurate and reproducible results in their studies of Topoisomerase IIBeta protein.