TNF-R1 Polyclonal Antibody

The protein encoded by TNFRSF1A (TNF receptor superfamily member 1A) is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

The TNF-R1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of TNF-R1 protein expression in various biological samples. This antibody is produced using advanced techniques, ensuring high affinity and specificity towards TNF-R1.

TNF-R1, also known as tumor necrosis factor receptor 1, plays a crucial role in mediating the biological effects of tumor necrosis factor-alpha (TNF-α). It is a transmembrane receptor that belongs to the TNF receptor superfamily. TNF-R1 is involved in various cellular processes, including apoptosis, inflammation, and immune response regulation.

The TNF-R1 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of TNF-R1 protein expression in different sample types.

This antibody is manufactured using high-quality materials and undergoes rigorous quality control procedures to ensure consistent and reliable results. It is supplied as a liquid formulation, ready to use for immediate application. The TNF-R1 Polyclonal Antibody is compatible with a wide range of experimental conditions and can be used in both research and clinical settings.

In summary, the TNF-R1 Polyclonal Antibody is a valuable tool for researchers and clinicians studying the role of TNF-R1 in various biological processes. Its high specificity, sensitivity, and versatility make it an essential component in the investigation of TNF-R1-related pathways and diseases.