TFIIH p44 Polyclonal Antibody

GTF2H2 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. GTF2H2 is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.

Introducing the TFIIH p44 Polyclonal Antibody, a cutting-edge scientific tool designed to revolutionize your research endeavors. This meticulously crafted antibody is specifically engineered to target and detect the TFIIH p44 protein, a crucial component of the transcription factor IIH (TFIIH) complex.

With its exceptional specificity and sensitivity, this polyclonal antibody offers unparalleled accuracy in identifying and quantifying TFIIH p44 protein expression levels in various biological samples. Its high affinity ensures reliable and reproducible results, enabling researchers to delve deeper into the intricate mechanisms of transcriptional regulation.

The TFIIH p44 Polyclonal Antibody boasts an advanced formulation, meticulously optimized to deliver exceptional performance across a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its versatility allows for seamless integration into diverse experimental protocols, facilitating comprehensive investigations into TFIIH p44 protein dynamics and interactions.

Crafted with utmost precision, this antibody undergoes rigorous quality control measures to ensure batch-to-batch consistency and reliability. Its exceptional stability and long shelf life guarantee consistent performance, making it an indispensable tool for both basic and clinical research.

In summary, the TFIIH p44 Polyclonal Antibody represents a breakthrough in scientific innovation, offering researchers an invaluable resource to unravel the complexities of TFIIH p44 protein function. With its exceptional specificity, sensitivity, and versatility, this antibody is poised to elevate your research to unprecedented heights.