TdT Polyclonal Antibody

DNTT is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

The TdT Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection of terminal deoxynucleotidyl transferase (TdT) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human TdT protein. The resulting polyclonal antibody exhibits high affinity and specificity towards TdT, making it an ideal tool for various applications such as western blotting, immunohistochemistry, and flow cytometry.

The TdT Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using immobilized TdT protein. This ensures that the antibody is free from non-specific binding and contaminants, resulting in highly reproducible and reliable results. The antibody is also validated for use in various species, including human, mouse, and rat, making it a versatile reagent for researchers working in different fields.

In summary, the TdT Polyclonal Antibody is a high-quality immunological reagent that offers exceptional sensitivity and specificity for the detection of TdT in various biological samples. Its versatility and reliability make it an essential tool for researchers working in fields such as immunology, oncology, and developmental biology.