TBC1D4 Polyclonal Antibody

TBC1D4 (TBC1 domain family member 4) is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by TBC1D4 is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains  (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

The TBC1D4 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of TBC1D4 protein expression in various biological samples. This antibody is produced through a rigorous process, ensuring its high affinity and sensitivity towards TBC1D4.

The TBC1D4 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its versatility allows for the precise localization and quantification of TBC1D4 protein in different tissues and cell types.

With its superior specificity, this antibody enables researchers to investigate the role of TBC1D4 in cellular processes such as glucose metabolism, insulin signaling, and vesicle trafficking. Its reliable performance guarantees accurate and reproducible results, facilitating the advancement of scientific knowledge in these areas.

Furthermore, the TBC1D4 Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency. Its high purity and low background staining contribute to the generation of clear and reliable data, enhancing the reliability of experimental findings.

In summary, the TBC1D4 Polyclonal Antibody is an indispensable tool for researchers seeking to explore the intricate mechanisms underlying TBC1D4 protein function. Its exceptional specificity, versatility, and reliability make it an ideal choice for a wide range of applications, ultimately contributing to the advancement of scientific understanding in the field.