TAF II p250 Polyclonal Antibody

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF1 (TATA-box binding protein associated factor 1) encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of TAF1 results in multiple transcript variants. TAF1 is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons.

The TAF II p250 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of TAF II p250 protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.

The TAF II p250 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunoprecipitation, and immunofluorescence. It enables accurate and precise identification of TAF II p250 protein, facilitating comprehensive research in the field of transcriptional regulation.

With its superior specificity, this antibody guarantees minimal cross-reactivity with other proteins, ensuring accurate and reliable results. Its robust and consistent performance makes it an ideal choice for both basic research and clinical applications.

The TAF II p250 Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for immediate implementation in laboratory workflows. It is provided in a stable formulation, ensuring long-term storage without compromising its quality and performance.

Choose the TAF II p250 Polyclonal Antibody for its exceptional specificity, reliability, and versatility, and unlock new possibilities in your research endeavors.