Syk Polyclonal Antibody

SYK (spleen associated tyrosine kinase) encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for SYK.

The SYK Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of spleen tyrosine kinase (SYK) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human SYK protein, followed by affinity purification using a column containing immobilized SYK protein. The resulting polyclonal antibody exhibits high affinity and specificity towards SYK protein, with minimal cross-reactivity to other proteins.

The SYK Polyclonal Antibody is suitable for a wide range of applications, including western blotting, immunoprecipitation, immunohistochemistry, and flow cytometry. It has been validated for use in human, mouse, and rat samples, and has been shown to detect endogenous SYK protein in various cell lines and tissues.

This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different experimental setups. The SYK Polyclonal Antibody is a reliable and effective tool for researchers studying the role of SYK protein in various physiological and pathological processes.