Stat5a Polyclonal Antibody

Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Stat5a and Stat5b are independently regulated and activated in various cell types. For instance, interferon treatment predominantly activates Stat5a in U-937 cells and Stat5b in HeLa cells.

The STAT5a Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of STAT5a protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

STAT5a, a member of the signal transducer and activator of transcription (STAT) family, plays a crucial role in mediating cellular responses to cytokines and growth factors. It is involved in the regulation of diverse biological processes, including cell proliferation, differentiation, and survival. The STAT5a Polyclonal Antibody recognizes the phosphorylated and non-phosphorylated forms of STAT5a, enabling comprehensive analysis of its activation status.

This antibody exhibits outstanding specificity, exhibiting minimal cross-reactivity with other STAT family members or unrelated proteins. It demonstrates high sensitivity, allowing for the detection of low-abundance STAT5a protein levels. The STAT5a Polyclonal Antibody also exhibits excellent reproducibility, ensuring consistent and reliable results across multiple experiments.

The STAT5a Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for easy handling and storage. This antibody has been rigorously tested to ensure optimal performance, providing researchers with a valuable tool for their studies on STAT5a signaling pathways.

In summary, the STAT5a Polyclonal Antibody is a superior reagent that offers exceptional specificity, sensitivity, and reproducibility for the detection and quantification of STAT5a protein. Its versatility in various applications makes it an indispensable tool for researchers investigating the role of STAT5a in cellular processes and disease mechanisms.