Stat5 Polyclonal Antibody

The protein encoded by STAT5A (signal transducer and activator of transcription 5A) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of STAT5A is found to induce the expression of BCL2L1/BCL-X (L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for STAT5A.

The Stat5 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Signal Transducer and Activator of Transcription 5 (Stat5) protein. This antibody is produced using advanced techniques to ensure exceptional quality and performance.

The Stat5 Polyclonal Antibody exhibits a high affinity towards Stat5 protein, enabling accurate and sensitive detection in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both phosphorylated and non-phosphorylated forms of Stat5, allowing for comprehensive analysis of its activation status.

With its exceptional specificity, this antibody ensures minimal cross-reactivity with other proteins, ensuring reliable and precise results. It has been extensively validated in various experimental conditions, guaranteeing consistent performance and reproducibility.

The Stat5 Polyclonal Antibody is supplied in a convenient and ready-to-use format, making it suitable for immediate use in research laboratories and diagnostic settings. It is provided in a liquid formulation, allowing for easy handling and reducing the risk of sample contamination.

This antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reliability. It is produced using high-quality materials and undergoes rigorous testing to meet the highest standards of performance and purity.

In summary, the Stat5 Polyclonal Antibody is a valuable tool for researchers and clinicians involved in the study of Stat5 protein and its role in various cellular processes. Its exceptional specificity, reliability, and ease of use make it an essential component of any laboratory or diagnostic setting.