Smad4 Polyclonal Antibody

SMAD4 encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of SMAD4 forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

The Smad4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Smad4 protein in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been purified and validated for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Smad4 Polyclonal Antibody is a reliable tool for researchers studying the TGF-β signaling pathway, as Smad4 is a key mediator of this pathway. This antibody has been extensively tested and validated for its specificity and sensitivity, ensuring accurate and reproducible results.

The Smad4 Polyclonal Antibody is supplied in a convenient format, with a concentration of 1 mg/ml. It is suitable for use in a variety of species, including human, mouse, and rat. This antibody is also available in a range of sizes to suit different experimental needs.

Overall, the Smad4 Polyclonal Antibody is a high-quality and reliable tool for researchers studying the TGF-β signaling pathway and its role in various biological processes. Its specificity, sensitivity, and versatility make it an essential tool for any laboratory working in this field.