Smad2/3 Polyclonal Antibody

Mothers against decapentaplegic homolog 2 encoded by SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF) -beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

The Smad2/3 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Smad2 and Smad3 proteins in various biological samples. This antibody is produced using high-quality polyclonal antibodies that have been extensively validated for their specificity and sensitivity. The Smad2/3 Polyclonal Antibody is ideal for use in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is designed to recognize both phosphorylated and non-phosphorylated forms of Smad2 and Smad3 proteins, making it an excellent tool for studying the regulation of Smad signaling pathways. The Smad2/3 Polyclonal Antibody is also highly specific, with minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The Smad2/3 Polyclonal Antibody is supplied in a convenient format, with a concentration of 1 mg/ml, making it easy to use in a variety of applications. This antibody is also available in a range of sizes, allowing researchers to choose the most appropriate size for their specific needs.

Overall, the Smad2/3 Polyclonal Antibody is a high-quality, reliable, and specific antibody that is ideal for studying Smad2 and Smad3 proteins in a variety of biological samples. Its sensitivity and specificity make it an excellent tool for researchers studying the regulation of Smad signaling pathways and their role in various biological processes.