Smad2 Polyclonal Antibody

Mothers against decapentaplegic homolog 2 encoded by SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

The Smad2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The Smad2 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to accurately quantify and visualize Smad2 protein levels in tissues, cells, and other biological specimens.

With its superior sensitivity, this antibody allows for the detection of low-abundance Smad2 protein, making it an ideal choice for studies requiring precise quantification. Its robust performance ensures reliable and reproducible results, facilitating accurate data interpretation and analysis.

The Smad2 Polyclonal Antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and reliability. It is validated for use in various species, including human, mouse, and rat, making it a versatile tool for researchers working with different model systems.

Furthermore, this antibody is provided in a convenient and ready-to-use format, eliminating the need for time-consuming and complex preparation steps. Its long shelf life and stability ensure consistent performance over an extended period, minimizing experimental variability.

In summary, the Smad2 Polyclonal Antibody is a highly reliable and efficient tool for the detection and analysis of Smad2 protein expression. Its exceptional sensitivity, specificity, and versatility make it an invaluable asset for researchers in the fields of molecular biology, cell biology, and biomedical research.