Smad2 Polyclonal Antibody

Mothers against decapentaplegic homolog 2 encoded by SMAD2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

The Smad2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Smad2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The Smad2 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously validated to provide reliable and reproducible results, making it an ideal choice for both research and diagnostic purposes.

With its superior sensitivity, this antibody enables the detection of even low levels of Smad2 protein, allowing for accurate quantification and analysis. Its polyclonal nature ensures recognition of multiple epitopes, enhancing the versatility and reliability of the antibody.

The Smad2 Polyclonal Antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reliability. It is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation steps.

In summary, the Smad2 Polyclonal Antibody is a highly reliable and sensitive tool for the detection and analysis of Smad2 protein expression. Its exceptional performance, versatility, and ease of use make it an essential component for any laboratory or research facility working in the field of molecular biology and cellular signaling pathways.