Smad1/5/9 Polyclonal Antibody

Mothers against decapentaplegic homolog 1 encoded by SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

The Smad1/5/9 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Smad1, Smad5, and Smad9 proteins. This antibody is produced using advanced techniques to ensure high affinity and sensitivity, making it suitable for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The Smad1/5/9 Polyclonal Antibody exhibits exceptional specificity towards its target proteins, enabling accurate and precise results. It recognizes endogenous levels of Smad1, Smad5, and Smad9 proteins, making it an ideal choice for studying the signaling pathways mediated by these proteins.

This antibody is manufactured using high-quality materials and undergoes rigorous quality control procedures to ensure consistent performance and reproducibility. It has been extensively validated in various experimental conditions, demonstrating its reliability and robustness.

The Smad1/5/9 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy handling and convenient storage. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps.

With its exceptional specificity, high sensitivity, and reliable performance, the Smad1/5/9 Polyclonal Antibody is an indispensable tool for researchers studying the Smad signaling pathway and its involvement in various cellular processes.