Smad1 Polyclonal Antibody

Mothers against decapentaplegic homolog 1 encoded by SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

The Smad1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Smad1 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional performance and reliability.

The Smad1 Polyclonal Antibody exhibits a high affinity towards the Smad1 protein, enabling accurate and precise detection even at low concentrations. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody is produced using state-of-the-art recombinant technology, ensuring batch-to-batch consistency and minimizing any potential variability. It has been rigorously tested to ensure minimal cross-reactivity with other related proteins, ensuring specificity and reliability in experimental results.

The Smad1 Polyclonal Antibody is supplied as a liquid formulation, making it convenient and easy to use. It is provided in a ready-to-use format, eliminating the need for any additional preparation steps. The antibody is stable and can be stored at recommended temperatures for extended periods without compromising its performance.

With its exceptional sensitivity, specificity, and reliability, the Smad1 Polyclonal Antibody is an indispensable tool for researchers and scientists studying the Smad1 signaling pathway. Its superior performance and ease of use make it an ideal choice for a wide range of applications in both basic research and clinical settings.