SLP-76 Polyclonal Antibody

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

The SLP-76 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of SLP-76 protein expression in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The SLP-76 Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate and precise quantification of SLP-76 protein levels. Its polyclonal nature allows for enhanced recognition of multiple epitopes, ensuring robust and consistent results across different experimental conditions.

This antibody has been rigorously tested and validated to ensure minimal cross-reactivity with other proteins, guaranteeing reliable and specific detection of SLP-76. Its high affinity and avidity enable efficient binding to the target protein, facilitating the detection of even low-abundance SLP-76 molecules.

The SLP-76 Polyclonal Antibody is manufactured using state-of-the-art techniques and quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

With its exceptional performance characteristics and versatility, the SLP-76 Polyclonal Antibody is an indispensable tool for researchers and scientists studying SLP-76 protein function and its involvement in various cellular processes. Its reliable and accurate detection capabilities make it an ideal choice for both basic research and clinical applications.

Choose the SLP-76 Polyclonal Antibody for unparalleled sensitivity, specificity, and reliability in your SLP-76 protein analysis.