Skp2 p45 Polyclonal Antibody

SKP2 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. S-phase kinase-associated protein 2 encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.

The Skp2 p45 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Skp2 p45 protein expression in various biological samples. This antibody has been extensively validated and exhibits exceptional sensitivity and specificity, making it an ideal choice for researchers in the field of cell biology and cancer research.

The Skp2 p45 Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It has been rigorously tested for cross-reactivity with other proteins to ensure accurate and reliable results. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior performance characteristics, the Skp2 p45 Polyclonal Antibody enables researchers to confidently investigate the role of Skp2 p45 protein in cellular processes and disease progression. Its high affinity and specificity allow for precise and accurate quantification of Skp2 p45 expression levels, facilitating a deeper understanding of its biological functions.

The Skp2 p45 Polyclonal Antibody is supplied in a convenient and user-friendly format, ensuring ease of use and storage. It is available in various sizes to accommodate different experimental needs. Each batch is accompanied by detailed technical information, including recommended protocols and storage conditions, to ensure optimal performance.

In summary, the Skp2 p45 Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of Skp2 p45 protein expression. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers in the field of cell biology and cancer research.