SIRT1 Polyclonal Antibody

SIRT1 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

The SIRT1 Polyclonal Antibody is a highly specific and reliable tool for the detection and quantification of SIRT1 protein levels in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

SIRT1, also known as NAD-dependent deacetylase sirtuin-1, is a crucial protein involved in various cellular processes, including DNA repair, metabolism, and aging. It plays a pivotal role in regulating gene expression and maintaining cellular homeostasis. The SIRT1 Polyclonal Antibody recognizes an epitope within the N-terminal region of SIRT1, ensuring high specificity and sensitivity in detecting this protein.

This antibody has been meticulously developed using state-of-the-art techniques and rigorously tested to ensure its superior performance. It exhibits minimal cross-reactivity with other sirtuin family members, ensuring accurate and reliable results. The SIRT1 Polyclonal Antibody demonstrates excellent signal-to-noise ratio, enabling precise quantification of SIRT1 protein levels in complex biological samples.

In IHC applications, this antibody provides clear and specific staining of SIRT1 in various tissue types, allowing for detailed localization and visualization of SIRT1 expression patterns. In IF applications, it enables the detection of SIRT1 in cellular compartments, facilitating the study of its subcellular localization and dynamics. In WB applications, this antibody reliably detects SIRT1 protein bands at the expected molecular weight, ensuring accurate quantification and analysis.

The SIRT1 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming antibody preparation. It is available in various sizes to accommodate different experimental requirements. This antibody is manufactured under strict quality control standards, ensuring batch-to-batch consistency and reproducibility.

In summary, the SIRT1 Polyclonal Antibody is a highly specific and reliable tool for the detection and quantification of SIRT1 protein levels. Its exceptional performance in IHC, IF, and WB applications, along with its high specificity and sensitivity, make it an invaluable asset for researchers studying SIRT1 and its role in various biological processes.