Shc Polyclonal Antibody

SHC1 encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

The SHC polyclonal antibody is a highly specific and reliable tool for the detection and analysis of SHC proteins in various biological samples. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reproducibility.

The SHC polyclonal antibody exhibits exceptional sensitivity and specificity, enabling accurate and precise quantification of SHC proteins in complex biological matrices. It recognizes multiple isoforms of SHC, making it a versatile tool for studying the diverse functions and signaling pathways associated with these proteins.

This antibody has been extensively validated in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It consistently delivers robust and consistent results, allowing researchers to confidently investigate the expression, localization, and interaction of SHC proteins in different cell types and tissues.

The SHC polyclonal antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, ensuring ease of use and compatibility with a wide range of experimental protocols.

With its exceptional performance and reliability, the SHC polyclonal antibody is an indispensable tool for researchers studying the role of SHC proteins in various biological processes. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications, facilitating a deeper understanding of SHC protein function and its implications in disease mechanisms.