Sgo1 Polyclonal Antibody

Shugoshin-like 1 encoded by SGOL1 is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID: 18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID: 25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.

The Sgo1 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Sgo1 protein expression in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional sensitivity and specificity.

The Sgo1 Polyclonal Antibody exhibits outstanding performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to accurately investigate the expression, localization, and function of Sgo1 protein in diverse experimental settings.

This antibody is produced using high-quality materials and undergoes rigorous quality control measures to guarantee consistent and reproducible results. Its exceptional affinity and selectivity towards Sgo1 protein make it an ideal choice for researchers seeking to explore the intricate mechanisms and roles of Sgo1 in cellular processes.

With its superior performance and reliability, the Sgo1 Polyclonal Antibody is an indispensable tool for scientists and researchers in the fields of cell biology, molecular biology, and cancer research. It empowers them to unravel the complexities of Sgo1 protein and contribute to the advancement of scientific knowledge and understanding.

Choose the Sgo1 Polyclonal Antibody for its exceptional quality, reliability, and versatility, and unlock new insights into the fascinating world of Sgo1 protein biology.