RUNX2 Polyclonal Antibody

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Runt-related transcription factor 2 is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

The RUNX2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of RUNX2 protein in various biological samples. This antibody has been extensively validated and exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The RUNX2 Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and batch-to-batch consistency. It has been rigorously tested to ensure minimal cross-reactivity with other proteins, guaranteeing accurate and reliable results.

With its superior sensitivity, this antibody allows for the detection of even low levels of RUNX2 protein, making it an ideal choice for researchers working with limited sample quantities. Its high specificity ensures minimal background noise, enabling precise and accurate quantification of RUNX2 expression.

The RUNX2 Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming and complex preparation steps. Its long shelf life and stability make it a cost-effective solution for long-term storage and repeated use.

In summary, the RUNX2 Polyclonal Antibody is a highly reliable and efficient tool for the detection and quantification of RUNX2 protein. Its exceptional sensitivity, specificity, and ease of use make it an invaluable asset for researchers in various fields, including molecular biology, cell biology, and cancer research.