RREB1 Polyclonal Antibody

The protein encoded by RREB1 (ras responsive element binding protein 1) is a zinc finger transcription factor that binds to RAS-responsive elements  (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for RREB1.

The RREB1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of RREB1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human RREB1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The RREB1 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 120 kDa in Western blot analysis of human, mouse, and rat cell lysates. In addition, the antibody has been shown to stain RREB1-positive cells in formalin-fixed paraffin-embedded tissue sections of human breast cancer and colon cancer.

This antibody is an essential tool for researchers studying the function and regulation of RREB1 protein in various biological processes, including cell proliferation, differentiation, and apoptosis. It is also useful for diagnostic applications, such as the detection of RREB1 expression in cancer tissues. The RREB1 Polyclonal Antibody is available in various sizes and formats to meet the specific needs of different research applications.