Ribosomal Protein L22 Polyclonal Antibody

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. RPL22 (ribosomal protein L22) encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3; 21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26.

The Ribosomal Protein L22 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Ribosomal Protein L22 in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of Ribosomal Protein L22. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Ribosomal Protein L22 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize Ribosomal Protein L22 in a variety of species, including human, mouse, and rat. The antibody has also been shown to have minimal cross-reactivity with other ribosomal proteins, ensuring high specificity in detection.

This antibody is an essential tool for researchers studying the role of Ribosomal Protein L22 in various biological processes, including protein synthesis, cell growth, and differentiation. Its high sensitivity and specificity make it an ideal choice for detecting even low levels of Ribosomal Protein L22 in complex biological samples. With its reliable performance and consistent results, the Ribosomal Protein L22 Polyclonal Antibody is a valuable addition to any research laboratory.