Rhotekin Polyclonal Antibody

RTKN (rhotekin) encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

The Rhotekin Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Rhotekin protein in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards Rhotekin.

Rhotekin is a key regulator of Rho signaling pathway, which plays a crucial role in various cellular processes such as cell migration, adhesion, and cytoskeletal organization. Dysregulation of Rho signaling has been implicated in numerous diseases, including cancer, cardiovascular disorders, and neurological disorders. Therefore, accurate measurement of Rhotekin protein levels is essential for understanding the underlying mechanisms of these diseases and developing targeted therapeutic interventions.

The Rhotekin Polyclonal Antibody exhibits exceptional performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both endogenous and recombinant Rhotekin protein with high specificity, enabling precise and reliable quantification. The antibody demonstrates minimal cross-reactivity with other related proteins, ensuring accurate and specific detection of Rhotekin.

This antibody is supplied as a purified and lyophilized form, ensuring long-term stability and ease of use. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified protein samples. The Rhotekin Polyclonal Antibody is validated for use in multiple species, including human, mouse, and rat, making it a versatile tool for various research applications.

In summary, the Rhotekin Polyclonal Antibody is a highly reliable and specific reagent for the detection and quantification of Rhotekin protein. Its exceptional performance, compatibility with various applications and sample types, and broad species reactivity make it an invaluable tool for researchers studying Rho signaling pathway and its implications in various diseases.