RFWD3 Polyclonal Antibody

RFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. (PMID: 20173098 ) From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3.

The RFWD3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of RFWD3 protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and rigorous quality control measures to ensure optimal performance and reliability.

The RFWD3 Polyclonal Antibody exhibits exceptional affinity and specificity towards the RFWD3 protein, enabling accurate and precise detection in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both endogenous and recombinant RFWD3 protein, making it a versatile tool for researchers working in diverse fields.

This antibody is produced using high-quality materials and state-of-the-art manufacturing processes, resulting in a product that consistently delivers robust and reproducible results. It has been extensively validated in various experimental conditions to ensure its reliability and consistency.

The RFWD3 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps. The antibody is also available in different sizes to accommodate various experimental needs.

With its exceptional sensitivity, specificity, and reliability, the RFWD3 Polyclonal Antibody is an indispensable tool for researchers studying RFWD3 protein expression and its role in cellular processes. Its superior performance and ease of use make it an ideal choice for both basic research and clinical applications.