RelB Polyclonal Antibody

Transcription factors of the nuclear factor κB (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses. There are five family members in mammals: relA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins. NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression. NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleus.

The RelB Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of RelB protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

The RelB Polyclonal Antibody exhibits exceptional affinity and selectivity towards RelB, a member of the NF-κB family of transcription factors. It recognizes both the full-length and cleaved forms of RelB, making it suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior sensitivity, this antibody enables accurate and reliable quantification of RelB protein levels, even in samples with low expression. Its robust performance ensures consistent and reproducible results, making it an ideal choice for both research and diagnostic purposes.

The RelB Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with various sample types, including cell lysates, tissue homogenates, and serum, facilitating versatile experimental designs.

Furthermore, this antibody has been extensively validated in multiple experimental settings, ensuring its reliability and performance. It exhibits minimal cross-reactivity with other NF-κB family members, ensuring specific detection of RelB without interference from closely related proteins.

In summary, the RelB Polyclonal Antibody offers researchers and clinicians a powerful tool for studying and understanding the role of RelB in various biological processes. Its high specificity, sensitivity, and ease of use make it an indispensable asset in the field of molecular biology and immunology.