RCC1 Polyclonal Antibody

The Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle and nuclear transport. Like other small GTPases, Ran is active in its GTP-bound form and inactive in its GDP-bound form. Nuclear RanGTP concentration is maintained through nuclear localization of guanine nucleotide exchange factor (GEF) activity, which catalyzes the exchange of bound GDP for GTP. RCC1 (regulator of chromatin condensation 1) is the only known RanGEF. RCC1 is dynamically chromatin-bound throughout the cell cycle, and this localization is required for mitosis to proceed normally. Appropriate association of RCC1 with chromatin is regulated through amino-terminal phosphorylation and methylation. RCC1 regulation of RanGTP levels in response to histone modifications regulates nuclear import during apoptosis. In mitosis RCC1 is phosphorylated at Ser11, possibly by cyclinB/cdc2. This phosphorylation may play a role in RCC1 interaction with chromatin and its RanGEF activity.

The RCC1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Regulator of Chromosome Condensation 1 (RCC1) protein. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and consistency in every batch.

The RCC1 Polyclonal Antibody exhibits exceptional affinity and selectivity towards RCC1, making it an ideal choice for various applications, including immunohistochemistry, western blotting, and immunofluorescence. It has been extensively validated and proven to provide reliable and reproducible results.

With its superior sensitivity, the RCC1 Polyclonal Antibody allows for the detection of even low levels of RCC1 protein in various sample types, including cell lysates, tissue extracts, and biological fluids. Its robust performance ensures accurate quantification and precise localization of RCC1 in both research and clinical settings.

The RCC1 Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming preparation. It is provided in a liquid formulation, allowing for easy handling and minimizing the risk of sample contamination.

Furthermore, this antibody is manufactured under strict quality control measures, ensuring batch-to-batch consistency and reliability. It is produced using high-quality materials and undergoes rigorous testing to guarantee optimal performance and long-term stability.

In summary, the RCC1 Polyclonal Antibody is a valuable tool for researchers and clinicians alike, offering exceptional sensitivity, specificity, and reliability in the detection and analysis of RCC1 protein. Its ease of use and consistent performance make it an essential component in various molecular biology and biomedical research applications.