RB3 Polyclonal Antibody

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.

The RB3 Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for use in a wide range of research applications. This antibody has been raised against a synthetic peptide corresponding to a region of the human RB3 protein, and has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence assays.

The RB3 Polyclonal Antibody is produced using state-of-the-art techniques, ensuring high purity and consistency from batch to batch. This antibody has been rigorously tested for specificity, and has been shown to recognize the RB3 protein with high affinity and selectivity. It is suitable for use in a variety of experimental systems, including cell culture, tissue samples, and animal models.

The RB3 Polyclonal Antibody is an essential tool for researchers studying the RB3 protein and its role in cellular processes such as cell cycle regulation, apoptosis, and DNA damage response. Its high sensitivity and specificity make it an ideal choice for detecting and quantifying RB3 protein expression levels in a variety of experimental settings.

Overall, the RB3 Polyclonal Antibody is a reliable and effective tool for researchers working in the fields of cell biology, molecular biology, and cancer research. Its high quality and versatility make it an essential component of any research program focused on understanding the complex mechanisms underlying cellular processes.