Rb Polyclonal Antibody

The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

The Rb Polyclonal Antibody is a highly specific and sensitive immunological tool designed for the detection and quantification of the retinoblastoma protein (Rb) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to a specific region of the Rb protein.

The Rb Polyclonal Antibody exhibits exceptional affinity and selectivity towards the Rb protein, enabling accurate and reliable results in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to provide consistent and reproducible results across different experimental conditions.

This antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for any additional preparation steps. The Rb Polyclonal Antibody is available in various sizes to accommodate different experimental requirements.

With its exceptional sensitivity and specificity, the Rb Polyclonal Antibody is an indispensable tool for researchers and scientists studying the role of the Rb protein in various biological processes, including cell cycle regulation, tumor suppression, and differentiation. Its reliable performance and consistent results make it an ideal choice for both basic research and clinical applications.

Order the Rb Polyclonal Antibody today and unlock new insights into the intricate mechanisms governed by the retinoblastoma protein.