PTTG1/2/3 Polyclonal Antibody

Pituitary tumor-transforming 1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. PTTG1 product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for PTTG1.

The PTTG1/2/3 Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect the expression of PTTG1, PTTG2, and PTTG3 proteins in various biological samples. This antibody has been extensively validated for use in Western blotting, immunohistochemistry, and immunofluorescence applications.

The PTTG1/2/3 Polyclonal Antibody is produced using high-quality immunogens and purified using advanced chromatography techniques to ensure maximum purity and specificity. This antibody has been rigorously tested to ensure that it does not cross-react with other proteins, ensuring accurate and reliable results.

This antibody is suitable for use in a wide range of research applications, including cancer research, cell biology, and developmental biology. It is also suitable for use in diagnostic applications, such as the detection of PTTG1/2/3 expression in clinical samples.

Overall, the PTTG1/2/3 Polyclonal Antibody is a highly reliable and specific tool for the detection of PTTG1, PTTG2, and PTTG3 proteins in various biological samples. Its high sensitivity and specificity make it an ideal choice for researchers and clinicians alike.