PTP1B Polyclonal Antibody

Protein tyrosine phosphatase, non-receptor type 1 by PTPN1 is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for PTPN1.

The PTP1B Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of protein tyrosine phosphatase 1B (PTP1B) in various biological samples. This antibody is produced through a rigorous process of immunization using a recombinant PTP1B protein, ensuring its high affinity and specificity towards the target protein.

The PTP1B Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. Its superior sensitivity allows for the detection of even low levels of PTP1B, enabling accurate and reliable results.

This antibody is manufactured using state-of-the-art techniques and undergoes stringent quality control measures to ensure batch-to-batch consistency and reproducibility. It is supplied as a liquid formulation, ready for immediate use, eliminating the need for time-consuming reconstitution.

The PTP1B Polyclonal Antibody is compatible with various sample types, including cell lysates, tissue extracts, and purified proteins. Its versatility and robustness make it an ideal choice for researchers and scientists working in the fields of cell signaling, cancer research, and drug discovery.

With its exceptional specificity, sensitivity, and reliability, the PTP1B Polyclonal Antibody is an indispensable tool for studying the role of PTP1B in cellular processes and disease mechanisms. Trust in its performance to advance your research and gain valuable insights into the intricate world of protein tyrosine phosphatases.