PTEN Polyclonal Antibody

PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. Pphosphatase and tensin homolog encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, t phosphatase and tensin homolog preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of PTEN is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.

The PTEN Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of PTEN protein expression in various biological samples. This antibody is produced using advanced recombinant DNA technology, ensuring high purity and batch-to-batch consistency.

The PTEN Polyclonal Antibody exhibits exceptional affinity and specificity towards PTEN, a tumor suppressor protein that plays a crucial role in regulating cell growth and division. It is widely recognized as a key player in various cellular processes, including apoptosis, cell migration, and DNA repair.

This antibody is validated for use in multiple applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been rigorously tested and proven to provide reliable and reproducible results across a wide range of sample types, including cell lysates, tissue sections, and whole-cell extracts.

The PTEN Polyclonal Antibody offers exceptional sensitivity, allowing for the detection of low levels of PTEN protein expression. Its high specificity ensures minimal cross-reactivity with other proteins, enabling accurate and precise quantification of PTEN levels in complex biological samples.

With its superior performance characteristics, the PTEN Polyclonal Antibody is an indispensable tool for researchers and scientists studying PTEN biology and its implications in various diseases, including cancer. Its reliable and consistent performance makes it an ideal choice for both basic research and clinical applications.

Order your PTEN Polyclonal Antibody today and unlock new insights into the intricate mechanisms of PTEN signaling pathway and its potential therapeutic implications.