PSMD3 Polyclonal Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSMD3 (proteasome 26S subunit, non-ATPase 3) encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in PSMD3 are associated with neutrophil count.

The PSMD3 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of PSMD3 protein expression in various biological samples. This antibody has been extensively validated for its superior performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

PSMD3, also known as 26S proteasome non-ATPase regulatory subunit 3, is an essential component of the 26S proteasome complex. It plays a crucial role in the degradation of ubiquitinated proteins, thereby regulating various cellular processes such as cell cycle progression, DNA repair, and protein quality control.

The PSMD3 Polyclonal Antibody has been developed using high-quality immunogens and advanced immunization techniques. It exhibits high affinity and specificity towards PSMD3, ensuring accurate and reliable results. This antibody has been rigorously tested against a wide range of cell lines and tissues, demonstrating its robust performance across various experimental conditions.

In IHC applications, the PSMD3 Polyclonal Antibody shows strong and specific staining of PSMD3 protein in formalin-fixed, paraffin-embedded tissues. It enables precise localization and visualization of PSMD3 expression, facilitating the identification of cellular compartments and subcellular structures associated with PSMD3 function.

For IF applications, the PSMD3 Polyclonal Antibody exhibits bright and specific staining of PSMD3 protein in fixed cells. It allows for the visualization of PSMD3 distribution and co-localization with other cellular markers, providing valuable insights into its subcellular localization and potential interactions.

In WB applications, the PSMD3 Polyclonal Antibody recognizes a single band of the expected molecular weight in cell lysates and tissue extracts. It enables accurate quantification of PSMD3 protein levels, allowing for the comparison of expression levels between different samples or experimental conditions.

Overall, the PSMD3 Polyclonal Antibody is a reliable and versatile tool for the detection and analysis of PSMD3 protein expression. Its high specificity, sensitivity, and robust performance make it an ideal choice for researchers studying the role of PSMD3 in various biological processes and diseases.