PRPF38A Polyclonal Antibody

PRPF38A (Pre-mRNA-splicing factor 38A) is a 312 amino acid nuclear protein that is likely required for pre-mRNA splicing. There are two isoforms of PRPF38A that are produced as a result of alternative splicing events. The gene encoding PRPF38A maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. There are about 3000 genes on chromosome 1 and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

The PRPF38A Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of PRPF38A protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, ensuring its exceptional sensitivity and specificity.

The PRPF38A Polyclonal Antibody exhibits a broad range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated for its outstanding performance in these techniques, providing accurate and reproducible results.

This antibody is produced using high-quality materials and undergoes rigorous quality control measures to ensure batch-to-batch consistency and reliability. Its exceptional affinity and selectivity towards PRPF38A protein make it an ideal choice for researchers and scientists working in the field of molecular biology and protein analysis.

The PRPF38A Polyclonal Antibody is supplied as a liquid formulation, allowing for easy and convenient handling. It is provided in a ready-to-use format, eliminating the need for time-consuming and complex preparation steps.

With its exceptional performance, reliability, and ease of use, the PRPF38A Polyclonal Antibody is an indispensable tool for studying the expression and function of PRPF38A protein in various biological systems.