PP2A-B55-Beta Polyclonal Antibody

The product of PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta) belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. PPP2R2B encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12.

The PP2A-B55-Beta Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of PP2A-B55-Beta protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The PP2A-B55-Beta Polyclonal Antibody exhibits exceptional sensitivity, enabling accurate and precise quantification of PP2A-B55-Beta protein levels. It has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

This antibody demonstrates excellent performance in a wide range of species, making it suitable for use in diverse research areas. Its robustness and consistency guarantee reliable and reproducible results, facilitating the investigation of PP2A-B55-Beta protein function and regulation.

The PP2A-B55-Beta Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming preparation steps. The antibody is also available in different sizes to accommodate various experimental requirements.

With its exceptional quality and performance, the PP2A-B55-Beta Polyclonal Antibody is an indispensable tool for researchers studying PP2A-B55-Beta protein and its involvement in cellular processes. Its high specificity, sensitivity, and versatility make it an ideal choice for both basic research and clinical applications.