PMS2/PMS2CL Polyclonal Antibody

The protein encoded by PMS2 (PMS1 homolog 2, mismatch repair system component) is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA (X)2E (X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in PMS2 have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

The PMS2/PMS2CL Polyclonal Antibody is a highly specific and sensitive antibody designed for use in various research applications. This antibody is produced using high-quality polyclonal antibodies that have been extensively validated for their specificity and sensitivity. The PMS2/PMS2CL Polyclonal Antibody is ideal for use in immunohistochemistry, western blotting, and other applications where high sensitivity and specificity are required. This antibody is suitable for use in a wide range of species and has been extensively tested to ensure its reliability and reproducibility. The PMS2/PMS2CL Polyclonal Antibody is an essential tool for researchers studying DNA repair, cancer biology, and other related fields. With its high specificity and sensitivity, this antibody is an excellent choice for researchers looking to obtain accurate and reliable results in their experiments.