PMS2 Polyclonal Antibody

PMS1 homolog 2, mismatch repair system component encoded by PMS2 is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. PMS1 homolog 2, mismatch repair system component forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by PMS2 that forms part of the active site of the nuclease. Mutations in PMS2 have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome.

The PMS2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of PMS2 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target protein.

The PMS2 Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to accurately assess the expression levels and localization of PMS2 protein in different tissues and cell types.

With its superior sensitivity and specificity, this antibody offers reliable and reproducible results, making it an invaluable tool for studying PMS2 protein function and its involvement in various cellular processes. Its versatility allows for comprehensive investigations in fields such as cancer research, genetic studies, and molecular biology.

The PMS2 Polyclonal Antibody is manufactured under stringent quality control measures to ensure batch-to-batch consistency and optimal performance. It is supplied in a convenient format, ready for immediate use, and is compatible with a variety of experimental protocols.

Choose the PMS2 Polyclonal Antibody for its exceptional quality, reliability, and versatility, and unlock new insights into the role of PMS2 protein in biological systems.