Plakophilin 2 Polyclonal Antibody

PKP2 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. PKP2 product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.

The Plakophilin 2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Plakophilin 2 protein expression in various biological samples. This antibody has been meticulously developed using advanced immunization techniques and exhibits exceptional affinity and selectivity towards Plakophilin 2.

Plakophilin 2, a member of the armadillo protein family, plays a crucial role in cell-cell adhesion and maintenance of tissue integrity. It is primarily found in desmosomes, specialized cell junctions that provide mechanical strength to tissues subjected to mechanical stress. Dysregulation of Plakophilin 2 expression has been implicated in various pathological conditions, including skin disorders and cardiac diseases.

The Plakophilin 2 Polyclonal Antibody has been rigorously validated for its specificity and sensitivity through various experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

This antibody is supplied as a liquid formulation, ready for immediate use in a variety of applications. It is compatible with multiple species, including human, mouse, and rat, making it a versatile tool for researchers working in diverse fields of study.

With its exceptional performance characteristics and broad applicability, the Plakophilin 2 Polyclonal Antibody is an indispensable tool for investigating the role of Plakophilin 2 in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications.