PKR Polyclonal Antibody

The protein encoded by EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2) is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA.

The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin.

Three transcript variants encoding two different isoforms have been found for EIF2AK2.The PKR Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of the protein kinase RNA-activated (PKR) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human PKR protein, and subsequently purified using protein A affinity chromatography.

The PKR Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody is suitable for use in both research and diagnostic settings, and is an essential tool for studying the role of PKR in various cellular processes, including stress response, apoptosis, and antiviral defense. With its high quality and reliability, the PKR Polyclonal Antibody is an indispensable reagent for any laboratory studying PKR biology.